Ca 2+ -CaM Dependent Inactivation of RyR2 Underlies Ca 2+ Alternans in Intact Heart

Altered Inactivation of Ca 2 Current and Ca 2 Release in Mouse Muscle

Functional impacts of the skeletal muscle-specific Ca 2 channel subunit 1 have previously been studied using coexpression with the cardiac 1C polypeptide in nonmuscle cells and primary-cultured myotubes of 1 -deficient mice. Data from single adult muscle fibers of / mice are not yet available. In the present study, we performed voltage clamp experiments on enzymatically isolated mature muscle f...

Altered Inactivation of Ca 2 Current and Ca 2 Release in Mouse Muscle Fibers Deficient

Functional impacts of the skeletal muscle-specific Ca 2 channel subunit 1 have previously been studied using coexpression with the cardiac 1C polypeptide in nonmuscle cells and primary-cultured myotubes of 1 -deficient mice. Data from single adult muscle fibers of / mice are not yet available. In the present study, we performed voltage clamp experiments on enzymatically isolated mature muscle f...

FGF-2 potentiates Ca(2+)-dependent inactivation of NMDA receptor currents in hippocampal neurons.

Peptide growth factors such as the neurotrophins and fibroblast growth factors have potent effects on synaptic transmission, development, and cell survival. We report that chronic (hours) treatment with basic fibroblast growth factor (FGF-2) potentiates Ca(2+)-dependent N-methyl-D-aspartate (NMDA) receptor inactivation in cultured hippocampal neurons. This effect is specific for the NMDA-subtyp...

Ca 2 + waves in the heart Leighton

Effect of Bay K 8644 ( 2 ) and the b 2 a Subunit on Ca 2 1 - dependent Inactivation in a 1 C Ca 2 1 Channels

Ca 2 1 currents recorded from Xenopus oocytes expressing only the a 1C pore-forming subunit of the cardiac Ca 2 1 channel show Ca 2 1 -dependent inactivation with a single exponential decay. This current-dependent inactivation is not detected for inward Ba 2 1 currents in external Ba 2 1 . Facilitation of pore opening speeds up the Ca 2 1 -dependent inactivation process and makes evident an ini...